In a series of tweets, he said: "LIBERATE MINNESOTA", "LIBERATE MICHIGAN" and then "LIBERATE VIRGINIA".
Protesters say the severe economic restrictions are hurting citizens, but health officials warn lifting them could spread infection.
The US saw its highly daily death toll on Thursday, recording 4,591 deaths in 24 hours.
It has the highest number of Covid-19 cases in the world, with over 672,200 confirmed. There have been over 33,000 deaths due to the virus.
Demonstrations calling on authorities to end the shutdown have occurred in Michigan, Ohio, North Carolina, Minnesota, Utah, Virginia and Kentucky.
Coronavirus: President Trump defends tweets against US states' lockdowns
He says some measures are "too tough", but health experts warn lifting them will increase infection.
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