By  Jan 2, 2020, 41 admitted hospital patients had been identified as having laboratory-confirmed 2019-nCoVinfection. Most of the infected patients were men (30 [73%] of 41); less than half had underlying diseases (13 [32%]), including  diabetes  (eight  [20%]),  hypertension  (six  [15%]),  and  cardiovascular  disease  (six  [15%]).  Median  age  was  49·0 years (IQR 41·0–58·0). 27 (66%) of 41 patients had been exposed to Huanan seafood market. One family cluster was found. Common symptoms at onset of illness were fever (40 [98%] of 41 patients), cough (31 [76%]), and myalgia or fatigue  (18  [44%]);  less  common  symptoms  were  sputum  production  (11  [28%]  of  39),  headache  (three  [8%]  of  38),haemoptysis (two [5%] of 39), and diarrhoea (one [3%] of 38).Dyspnoea developed in 22 (55%) of 40 patients (median time from illness onset to dyspnoea 8·0 days [IQR 5·0–13·0]). 26 (63%) of 41 patients had lymphopenia. All 41 patients had  pneumonia  with  abnormal  findings  on  chest  CT.  Complications  included  acute  respiratory  distress  syndrome  (12 [29%]), RNAaemia (six [15%]), acute cardiac injury (five [12%]) and secondary infection (four [10%]). 13 (32%) patients were admitted to an ICU and six (15%) died. Compared with non-ICU patients, ICU patients had higher plasma levels of IL2, IL7, IL10, GSCF, IP10, MCP1, MIP1A, and TNFα.